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Avidathepole Ivideyum movie revolves around Anirudhan and Sugumaran who are roommates and are both pharmaceutical company executives. Sugumaran is urbane and somewhat westernized in attitude, Anirudhan is more of a son-of-the-soil type. During a trip to Anirudhan's village, Sugumaran falls in love with Sujatha who is Anirudhan's sister. Concurrently, Anirudhan takes a liking for Neelima, who is Sugumaran's sister. The two couples marry and then face the realities of marriage due to their different upbringing and lifestyles.