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UFC on ESPN 34: Luque vs. Muhammad 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on April 16, 2022, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A welterweight rematch between Vicente Luque and Belal Muhammad headlined the event. The pair previously met at UFC 205, where Luque won the bout via first-round knockout.